H. Shindou

Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization

This study identifies PfLPLAT1 as essential for Plasmodium falciparum cell cycle progression and cytostome function, with its deficiency causing developmental arrest and morphological changes.

Impact of perinatal maternal docosahexaenoic acid-containing phospholipid synthesis on offspring growth and neurological symptoms

This study shows that maternal DHA-PL synthesis during fetal development affects offspring neuropsychiatric outcomes, but not postnatal growth or brain size.

Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells

This study shows that Lpcat1 deletion causes photoreceptor-specific apoptosis and increased mitochondrial ROS in mice, highlighting its role in lipid metabolism and retinal health.

Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.

The paper identifies key residues and an acyl-CoA-binding pocket in mouse LPCAT2 using homology modeling, providing structural insights for drug development against PAF-related diseases.

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

This study maintains engraftable quiescent HSCs in culture for 1 month using low cytokines, hypoxia, and high fatty acids.