Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells
P. Canales Herrerias, E. Crickx, M. Broketa, A. Sokal, G. Chenon, I. Azzaoui, A. Vandenberghe, A. Perima, B. Iannascoli, O. Richard-Le Goff, C. Castrillon, G. Mottet, D. Sterlin, A. Robbins, M. Michel, , P. Bruhns
This study identifies high-affinity autoreactive plasma cells in multiple organs of ITP patients, showing treatment resistance and suggesting therapy failure mechanisms.
bioRxiv · Jun 29, 2021 · PreprintImmunology