Author

P. Bruhns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. Iannascoli· 3 shared D. Sterlin· 3 shared P. England· 3 shared A. Sokal· 2 shared A. Vandenberghe· 2 shared B. Dupuy· 2 shared C. Guo· 2 shared E. Crickx· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

B. Iannascoli

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Optimization of neuromuscular blockade protocols in cynomolgus macaques: monitoring, doses and antagonism

H. Letscher, J. Lemaitre, E. Burban, R. Le Grand, P. Bruhns, F. Relouzat, A. Gouel-Cheron

This study evaluates neuromuscular blockade in cynomolgus macaques using rocuronium and atracurium, finding equivalent blockade depth at human clinical doses and successful reversal with sugammadex.

bioRxiv · Dec 22, 2023 · PreprintPathology

A monoclonal antibody collection for C. difficile typing

L. Hunault, P. England, F. Barbut, B. Iannascoli, O. Godon, F. Dejardin, C. Thomas, B. Dupuy, C. Guo, L. Macdonald, G. Gorochov, D. Sterlin, P. Bruhns

The paper develops a monoclonal antibody collection targeting C. difficile strains to improve research on clinically relevant ribotypes.

bioRxiv · Sep 21, 2023 · PreprintImmunology

Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology

L. Hunault, E. Auria, P. England, J. Deschamps, R. Briandet, V. Kremer, B. Iannascoli, L. Vidal-Maison, C. Guo, L. Macdonald, S. Pechine, C. Deneve-Larrazet, B. Dupuy, G. Gorochov, P. Bruhns, D. Sterlin

This study identifies monoclonal antibodies targeting C. difficile's S-layer protein, revealing both protective and detrimental effects on bacterial physiology.

bioRxiv · Sep 21, 2023 · PreprintMicrobiology

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

A. Bonaud, L. Gargowitsch, S. Gilbert, E. Rajan, P. Canales-Herrerias, D. Stockholm, N. Rahman, M. Collins, D. L. Hill, A. Alloatti, N. Alouche, S. Balor, V. Soldan, D. Gillet, J. Barbier, , M. Espeli

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.

A. Sokal, M. Broketa, A. Meola, G. Barba-Spaeth, I. Fernandez, S. Fourati, I. Azzaoui, A. de La Selle, A. Vandenberghe, A. Roeser, M. Bouvier-Alias, E. Crickx, L. Languille, M. Michel, B. Godeau, , M. Mahevas

The paper assesses how well mRNA vaccine-induced memory B cells recognize the Omicron variant of SARS-CoV-2 and finds that Omicron evades recognition more than previous variants.

bioRxiv · Dec 21, 2021 · PreprintImmunology

Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells

P. Canales Herrerias, E. Crickx, M. Broketa, A. Sokal, G. Chenon, I. Azzaoui, A. Vandenberghe, A. Perima, B. Iannascoli, O. Richard-Le Goff, C. Castrillon, G. Mottet, D. Sterlin, A. Robbins, M. Michel, , P. Bruhns

This study identifies high-affinity autoreactive plasma cells in multiple organs of ITP patients, showing treatment resistance and suggesting therapy failure mechanisms.

bioRxiv · Jun 29, 2021 · PreprintImmunology