M. Michel

Detection of Antibodies Against the African Parasite Trypanosoma brucei Using Synthetic glycosylphosphatidylinositol oligosaccharide fragments

The paper develops synthetic glycan fragments of T. brucei GPIs to detect antibodies against the parasite, showing they elicit both IgM and IgG responses, enabling diagnostic tests for African trypanosomiasis and Nagana.

Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals.

This study shows that Omicron BA.1 breakthrough infection in vaccinated individuals leads to long-term remodeling of memory B cells, enhancing neutralizing breadth and potency against common and BA.1 epitopes but not BA.5.

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

Cell surface composition and ionic strength mediate fast sedimentation in the cyanobacterium Synechococcus elongatus PCC 7942

This study identifies genetic and surface factors that cause a fast-sedimenting phenotype in a domesticated cyanobacterial strain.

Detection of orthologous genes with expression shifts linked to nickel hyperaccumulation across Eudicots

The paper identifies 31 orthologous gene groups with expression shifts linked to nickel hyperaccumulation across Eudicots using transcriptomic and phylogenetic analyses.

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.

The paper assesses how well mRNA vaccine-induced memory B cells recognize the Omicron variant of SARS-CoV-2 and finds that Omicron evades recognition more than previous variants.

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.

Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells

This study identifies high-affinity autoreactive plasma cells in multiple organs of ITP patients, showing treatment resistance and suggesting therapy failure mechanisms.

Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals.

The study compares memory B cell responses in naive and recovered individuals after mRNA vaccination, showing enhanced expansion and neutralization against variants in recovered patients.

Unique brewing-relevant properties of a strain of Saccharomyces jurei isolated from ash (Fraxinus excelsior)

This paper evaluates the brewing potential of Saccharomyces jurei, showing its ability to utilize maltotriose and produce distinct aroma profiles compared to other wild Saccharomyces species.

Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis

This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.

A reservoir of rituximab-resistant splenic memory B cells contributes to relapses after B-cell depletion therapy

A single droplet digital PCR for ESR1 activating mutations detection in plasma

This paper develops a multiplex droplet digital PCR assay for detecting ESR1 activating mutations in plasma, showing high sensitivity and concordance with NGS data.