Discovery of compounds inhibiting the ADP-ribosyltransferase activity of pertussis toxin
Y. Ashok, M. Miettinen, D. K. H. de Oliveira, M. Z. Tamirat, K. Näreoja, A. Tiwari, M. O. Hottiger, M. S. Johnson, L. Lehtiï, A. Pulliainen
This study identifies two small molecules that inhibit the ADP-ribosyltransferase activity of pertussis toxin, showing potential for targeted antibiotic development against Bordetella pertussis.
bioRxiv · Nov 4, 2019Microbiology