M. S. Johnson

Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies

This study identifies recurrent ERBB4 mutations with oncogenic potential and resistance to targeted therapies, suggesting clinical implications for treatment strategies.

Far From Home: Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

The paper evolves haploid and diploid yeast populations in different environments and finds common, unpredictable pleiotropic effects of adaptive mutations in non-home environments.

Airborne environmental DNA captures terrestrial vertebrate diversity in nature

This study uses airborne environmental DNA to detect terrestrial vertebrate diversity, finding it captures a quarter of known species in the area.

The molecular architecture of cell cycle arrest

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

This study shows mitochondrial-targeted antioxidants reduce oxidative stress and metabolic issues in PKD mouse models, improving disease progression and restoring metabolic pathways.

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

This study measures binding affinity landscapes of two influenza bnAbs to understand their evolutionary pathways and how they acquire breadth.

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

This study tracks phenotypic and molecular evolution in 205 yeast populations over 10,000 generations, revealing patterns of declining adaptability, mutation accumulation, and genetic parallelism.

Discovery of compounds inhibiting the ADP-ribosyltransferase activity of pertussis toxin

This study identifies two small molecules that inhibit the ADP-ribosyltransferase activity of pertussis toxin, showing potential for targeted antibiotic development against Bordetella pertussis.

Higher fitness yeast genotypes are less robust to deleterious mutations

The paper shows that more-fit yeast genotypes are less robust to deleterious mutations, as they exhibit lower mean and higher variance in mutation fitness effects.