TIM-3 blockade enhances ex vivo stimulated allogeneic NK cell therapy for relapsed murine neuroblastoma after hematopoietic cell transplant
A. Quamine, N. R. Mohrdieck, C. A. King, A. A. Griggs, J. M. Kline, M. M. Cho, S. P. Rinella, K. E. Tippins, P. D. Bates, L. Shi, L. Song, N. J. Hess, T. J. Kearl, B. D. Johnson, C. M. Capitini
This study shows that combining TIM-3 blockade with ex vivo stimulated allogeneic NK cells improves survival and reduces tumor growth in a murine neuroblastoma model after allo-HCT without increasing GVHD.
bioRxiv · Jul 9, 2024Immunology