An enhancer:involucrin regulatory module impacts human skin barrier adaptation out-of-Africa and modifies atopic dermatitis risk
Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, A. Quiggle, Inez Y. Oh, Eric Tycksen, Lisa Zhou, Yeriel D. Estrada, X.F. Colin C. Wong, Simon L. I. J. Denil, Scot J. Matkovich, Avner Shemer, John Common, Emma Guttman‐Yassky, Cristina de Guzman Strong
The paper identifies an enhancer-IVL regulatory module that evolved in humans and is associated with skin barrier adaptation and atopic dermatitis risk.
bioRxiv · Nov 5, 2019 · PreprintGenetics