Antitumor activity of a lectibody targeting cancer-associated high-mannose glycans
Y. J. Oh, M. Dent, A. R. Freels, Q. Zhou, C. B. Lebrilla, M. L. Merchant, N. Matoba
This study demonstrates that AvFc, a lectibody targeting high-mannose glycans, inhibits cancer cell migration and tumor growth in mice by blocking EGFR and IGF1R activation.
bioRxiv · Apr 28, 2021Cancer Biology