M. Dent

Characterization and utility of novel monoclonal antibodies to cholera toxin B subunit

The paper generates and characterizes monoclonal antibodies against cholera toxin B subunit and its variants, showing differential binding and functional properties.

Impact of glycoengineering and immunogenicity on the anti-cancer activity of a plant-made lectin-Fc fusion protein

This study shows that glycoengineering AvFc to remove plant glycans enhances its anti-cancer activity by improving Fc receptor binding and ADCC, while being unaffected by anti-drug antibodies.

Antitumor activity of a lectibody targeting cancer-associated high-mannose glycans

This study demonstrates that AvFc, a lectibody targeting high-mannose glycans, inhibits cancer cell migration and tumor growth in mice by blocking EGFR and IGF1R activation.

Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model

This paper evaluates the safety and efficacy of Avaren-Fc, a HCV-targeting lectibody, in a human liver chimeric mouse model, showing it prevents HCV infection without toxicity.