Molecular basis of a dominant SARS-CoV-2 Spike-derived epitope presented by HLA-A*02:01 recognised by a public TCR
C. Szeto, A. T. Nguyen, C. A. Lobos, D. S. Chatzileontiadou, D. Jayasinghe, E. J. Grant, A. Riboldi-Tunnicliffe, C. Smith, S. Gras
The paper reports the X-ray structure of a public TCR recognizing a SARS-CoV-2 Spike-derived epitope and shows its activation of polyfunctional CD8+ T cells in recovered patients.
bioRxiv · Aug 15, 2021Immunology