Author

B. C. Lechtenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

L. W. Richardson· 2 shared A. E. Au· 1 shared A. Riboldi-Tunnicliffe· 1 shared B. G. C. Lu· 1 shared C. C. Allison· 1 shared C. Grohmann· 1 shared D. J. Calleja· 1 shared D. Komander· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

L. W. Richardson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The unifying catalytic mechanism of the RING-between-RING E3 ligase family

X. S. Wang, T. R. Cotton, S. J. Trevelyan, L. W. Richardson, W. T. Lee, J. Silke, B. C. Lechtenberg

This study defines the core catalytic mechanism of RBR E3 ligases through structural and biochemical analysis of HOIL-1 and RNF216, revealing conserved features and an allosteric mechanism.

bioRxiv · Oct 11, 2022Biochemistry

Allosteric Regulation of the EphA2 Receptor Intracellular Region by Serine/Threonine Kinases

B. C. Lechtenberg, M. P. Gehring, T. P. Light, M. W. Matsumoto, K. Hristova, E. B. Pasquale

This study reveals two allosteric mechanisms by which serine/threonine phosphorylation of the EphA2 linker regulates its non-canonical signaling, providing insights into its role in cancer.

bioRxiv · Jan 28, 2021Biophysics

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry