Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions
J. A. Hensel, S.-A. E. Nicholas, E. R. Jellison, A. L. Kimble, A. Menoret, M. Ozawa, A. Rodriguez-Oquendo, A. T. Vella, P. A. Murphy
This study identifies Ptbp1 as a critical splice factor required for endothelial priming in atherogenic disturbed flow conditions, linking its regulation of splicing and NFκB activation to vascular inflammation.
bioRxiv · Jun 18, 2021 · PreprintCell Biology