E. R. Jellison

Cellular Senescence is a Double-Edged Sword in Regulating Aged Immune Responses to Influenza

This study shows that removing senescent cells in aged mice improves viral clearance but reduces immune memory formation after influenza infection.

SMAD4 and TGFβ are architects of inverse genetic programs during fate-determination of antiviral memory CD8 T cells

This study shows SMAD4 and TGFβ regulate gene expression in opposite ways to determine whether antiviral CD8 T cells become circulating or tissue-resident memory cells.

Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions

This study identifies Ptbp1 as a critical splice factor required for endothelial priming in atherogenic disturbed flow conditions, linking its regulation of splicing and NFκB activation to vascular inflammation.

A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue

This paper develops a method to isolate endothelial nuclei and RNA from archived frozen brain tissues, showing it reliably extracts endothelial RNA and correlates with whole-cell expression.

Identification of Splice Regulators of Fibronectin-EIIIA and EIIIB by Direct Measurement of Exon Usage in a Flow-Cytometry Based CRISPR Screen

The paper develops a flow-cytometry based CRISPR screen to identify splice regulators of fibronectin-EIIIA and EIIIB exons, identifying known and novel regulators and implicating TNFalpha and RIG-I-like signaling pathways.

ApoC-III overexpression and LDLr-/- protect mice from DSS-colitis: identifying a new role for lipoprotein metabolism in Tregs

This study shows that apoC-III overexpression and LDLr deficiency protect mice from DSS-colitis by increasing intestinal Tregs and IL-10, suggesting apoC-III as a potential therapeutic target for IBD.