XBP1s-Mediated Endoplasmic Reticulum Proteostasis Network Enhancement Can Selectively Improve the Folding and Secretion of an Osteogenesis Imperfecta-Causing Collagen-I Variant
A. S. DiChiara, N.-D. Doan, A. Bikovtseva, L. Rowley, V. Butty, M. Weis, D. Eyre, S. Lamande, J. F. Bateman, M. D. Shoulders
This study shows that activating the XBP1s pathway enhances collagen-I secretion from OI-causing G425S mutant fibroblasts without affecting wild-type collagen.
bioRxiv · Apr 15, 2021 · PreprintCell Biology