Author

M. D. Shoulders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. Yoon· 2 shared A. Bikovtseva· 1 shared A. I. Ponomarenko· 1 shared A. M. Phillips· 1 shared A. M. Ponomarenko· 1 shared A. S. DiChiara· 1 shared B. E. Ackermann· 1 shared C. B. Ogbunugafor· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

J. Yoon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Immune-Evasive Proline 283 Substitution in Influenza Nucleoprotein Increases Aggregation Propensity Without Altering the Native Structure

J. Yoon, Y. M. Zhang, C. Her, R. A. Grant, A. M. Ponomarenko, B. E. Ackermann, G. Debelouchina, M. D. Shoulders

The paper investigates how the Pro283 substitution in influenza nucleoprotein affects protein folding and aggregation, revealing it increases aggregation propensity without altering native structure.

bioRxiv · Sep 8, 2023Biophysics

The Host Cell's Endoplasmic Reticulum Proteostasis Network Profoundly Shapes the Protein Sequence Space Accessible to HIV Envelope

J. Yoon, E. E. Nekongo, J. E. Patrick, A. M. Phillips, A. I. Ponomarenko, S. J. Hendel, V. L. Butty, C. B. Ogbunugafor, Y.-S. Lin, M. D. Shoulders

This study shows that upregulating the host ER proteostasis network via the UPR reduces mutational tolerance of HIV Env, with some regions becoming more tolerant, suggesting host proteostasis influences HIV adaptation.

bioRxiv · Apr 24, 2021Biochemistry

XBP1s-Mediated Endoplasmic Reticulum Proteostasis Network Enhancement Can Selectively Improve the Folding and Secretion of an Osteogenesis Imperfecta-Causing Collagen-I Variant

A. S. DiChiara, N.-D. Doan, A. Bikovtseva, L. Rowley, V. Butty, M. Weis, D. Eyre, S. Lamande, J. F. Bateman, M. D. Shoulders

This study shows that activating the XBP1s pathway enhances collagen-I secretion from OI-causing G425S mutant fibroblasts without affecting wild-type collagen.

bioRxiv · Apr 15, 2021 · PreprintCell Biology