Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example
W. Yu, X. Zhao, A. S. Jalloh, Y. Zhao, B. Dinner, Y. Yang, S. Ouyang, Y. Li, T. Tian, Z. Zhao, R. Yang, M. Chen, G. Lauvau, Z. Guo, P. Wu, J. P. Li
The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.
bioRxiv · Sep 1, 2022 · PreprintImmunology