The Impact of Uremia and Intestinal Dysbiosis on Hepatic Drug Metabolism in a Rat Model of Progressive Chronic Kidney Disease
E. D. Hartjes, Y. J. Lim, T. J. Velenosi, K. F. Al, J. M. Macklaim, A. S. Kucey, G. Reid, J. P. Burton, G. B. Gloor, B. L. Urquhart
This study investigates how uremia and intestinal dysbiosis affect hepatic drug metabolism in a rat CKD model, finding that CYP3A2 and CYP2C11 are downregulated before dysbiosis and correlate with uremic toxins.
bioRxiv · Jan 29, 2019 · PreprintPharmacology & Toxicology