Author

Y. J. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. E. Gardiner· 3 shared T. Xu· 3 shared H. Lin· 2 shared W. M. Lee· 2 shared Y. Zheng· 2 shared A. Benda· 1 shared A. D. Duckworth· 1 shared A. S. Kucey· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBioengineering

E. E. Gardiner

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Author profile →

6 papers

Recent·Most cited

Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity

P. T. Kennedy, E. L. Saulters, A. D. Duckworth, Y. J. Lim, J. F. Woolley, J. R. Slupsky, M. S. Cragg, F. J. Ward, L. N. Dahal

This study shows that soluble CTLA-4 suppresses T-cell activation and promotes tumor growth in mice, and that blocking sCTLA-4 enhances anti-tumor immunity.

bioRxiv · Jun 5, 2023 · PreprintCancer Biology

Combined Scattering, Interferometric and Fluorescence Oblique Illumination for Live Cell Nanoscale Imaging

Y. Zheng, Y. J. Lim, H. Lin, T. Xu, C. Longbottom, V. Delghingaro-Augusto, Y. L. Thong, C. R. Parish, E. E. Gardiner, W. M. Lee

This paper develops a combined imaging system for live cell nanoscale imaging, enabling the simultaneous quantification of molecular targets, 3D cell morphodynamics, and intracellular organelle tracking.

bioRxiv · Jul 22, 2022Biophysics

Patterning High to Low Heterogenous Fluid Shear Stress Landscapes with Multiphoton Inner Laser Lithography (MILL) for Live Cell Adhesion and Translocation

Y. J. Lim, J. Zhang, H. Lin, T. Xu, Y. Li, Z. Zhang, S. M. Hicks, I. Chudinov, D. Y. Nechipurenko, E. E. Gardiner, w. m. Lee

The paper develops MILL, a technique to rapidly create 3D micro-patterned flow channels that mimic in vivo fluid shear stress environments, enabling real-time study of cell adhesion and translocation.

bioRxiv · Jun 17, 2022 · PreprintBioengineering

COSI for label-free multiparameter quantitative imaging of intra-thrombus stability in vitro.

Y. Zheng, S. Montague, Y. J. Lim, T. Xu, T. Xu, E. E. Gardiner, S. Lee

This paper introduces COSI, a label-free imaging method to quantify intra-thrombus mass and adhesive platelet dynamics under fluid shear stress with high precision.

bioRxiv · Aug 17, 2020 · PreprintBioengineering

Clustering of CD3ζ is sufficient to initiate T cell receptor signaling

Y. Ma, Y. J. Lim, A. Benda, J. Goyette, K. Gaus

This study shows that clustering of CD3ζ chains alone can initiate TCR signaling, including phosphorylation and calcium flux, in reconstituted cells.

bioRxiv · Feb 17, 2020 · PreprintImmunology

The Impact of Uremia and Intestinal Dysbiosis on Hepatic Drug Metabolism in a Rat Model of Progressive Chronic Kidney Disease

E. D. Hartjes, Y. J. Lim, T. J. Velenosi, K. F. Al, J. M. Macklaim, A. S. Kucey, G. Reid, J. P. Burton, G. B. Gloor, B. L. Urquhart

This study investigates how uremia and intestinal dysbiosis affect hepatic drug metabolism in a rat CKD model, finding that CYP3A2 and CYP2C11 are downregulated before dysbiosis and correlate with uremic toxins.

bioRxiv · Jan 29, 2019 · PreprintPharmacology & Toxicology