Author

A. S. Madsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. A. Olsen· 3 shared C. Moreno-Yruela· 2 shared N. Rajabi· 2 shared A. L. Nielsen· 1 shared A. Lucidi· 1 shared B. Svensson· 1 shared I. Galleano· 1 shared K. L. Larsen· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

C. A. Olsen

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3 papers

Recent·Most cited

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration

A. L. Nielsen, N. Rajabi, N. Kudo, K. L. Larsen, C. Moreno-Yruela, M. Baek, M. Fontenas, A. Lucidi, A. S. Madsen, M. Yoshida, C. A. Olsen

The paper develops potent, selective SIRT2 inhibitors with features suitable for cell culture and therapeutic development.

bioRxiv · Mar 20, 2020 · PreprintBiochemistry

An NAD+-dependent sirtuin depropionylase and deacetylase (Sir2La) from the probiotic bacterium Lactobacillus acidophilus NCFM

S. V. Olesen, N. Rajabi, B. Svensson, C. A. Olsen, A. S. Madsen

This paper identifies and characterizes Sir2La, a NAD+-dependent sirtuin from Lactobacillus acidophilus NCFM, showing it deacetylates and depropionylates lysine residues.

bioRxiv · Jan 23, 2018Biochemistry

Histone Deacetylase 11 is an ε-N-Myristoyllysine Hydrolase

C. Moreno-Yruela, I. Galleano, A. S. Madsen, C. A. Olsen

This study identifies HDAC11 as an ε-N-myristoyllysine hydrolase, showing it efficiently cleaves long-chain acyl modifications and is insensitive to common HDAC inhibitors but inhibited by macrocyclic hydroxamic acid peptides.

bioRxiv · Nov 1, 2017Biochemistry