M. Yoshida

Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization

This study identifies PfLPLAT1 as essential for Plasmodium falciparum cell cycle progression and cytostome function, with its deficiency causing developmental arrest and morphological changes.

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

Nitrogen signaling factor triggers a respiration-like gene expression program

The paper shows that NSF in fission yeast interacts with Hmt2 and shifts gene expression from fermentation to respiration-like, independent of carbon source.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Early human lung immune cell development and its role in epithelial cell fate

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

The paper identifies baseline AP-1 gene expression and gut microbial fucose/rhamnose degradation as factors negatively correlated with BNT162b2 mRNA vaccine-induced T-cell responses.

Inflammatory response induced in pulmonary embolic lung: Evaluation usinga reproducible murine pulmonary embolism model.

This paper establishes a reproducible murine pulmonary embolism model using small thrombi and evaluates the inflammatory response in the lung.

A case of mycobacteriosis associated with Mycobacterium pseudoshottsii in aquarium-reared fish in Japan

The paper reports the first isolation of Mycobacterium pseudoshottsii from aquarium-reared fish in Japan, identified through microbiological and genetic analyses.

Necessity of integrated genomic analysis to establish a designed knock-in mouse from CRISPR-Cas9-induced mutants

The paper demonstrates that integrated genomic analysis is necessary to accurately identify and establish a designed knock-in mouse strain from CRISPR-Cas9-induced mutants.

Rats emit unique distress calls in social inequality conditions

The paper shows rats emit unique distress calls in response to social inequality, distinct from physical stress.

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

This study shows SMN regulates mitochondrial metabolic maturation during myogenesis by controlling the MYOD-miRNA axis, with miR-1 and miR-206 supplementation restoring mitochondrial function in SMN-deficient cells.

Obesity associated with attenuated tissue immune cell responses in COVID-19

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

Does the rainbow trout ovarian fluid guide the spermatozoon on its way to the egg?

This study investigates how rainbow trout ovarian fluid influences sperm motility and chemotaxis during fertilization, finding it enhances sperm movement and induces chemotactic behavior.

Selection for non-specific adhesion is a driver of FimH evolution increasing Escherichia coli biofilm capacity

This study shows that mutations in FimH enhance E. coli's non-specific adhesion to surfaces, increasing biofilm formation despite reduced specific mannose binding.

A Novel DNA Chromatography Method to Distinguish M. abscessus Subspecies and Macrolide Susceptibility

This paper develops a DNA chromatography method to rapidly distinguish M. abscessus subspecies and determine macrolide susceptibility with high accuracy.

Common properties of visually-guided saccadic behavior and bottom-up attention in marmoset, macaque, and human

This study compares saccadic behavior and bottom-up attention across marmoset, macaque, and human in free-viewing and visually-guided tasks, finding similar kinematics and saliency responses.

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration

The paper develops potent, selective SIRT2 inhibitors with features suitable for cell culture and therapeutic development.

Distinct chemotactic behavior in the original Escherichia coli K-12 depending on forward-and-backward swimming, not on run-tumble movements

This study identifies a novel swimming behavior in E. coli K-12 strain ATCC10798, driven by forward-and-backward motion rather than run-tumble, linked to a mutation in FliC.

Evidence for a role for BK channels in the regulation of ADAM17 activity.

This study shows BK channels regulate ADAM17 activity in macrophages, with inhibition increasing TNF-α and IL-6R release, and activation reducing them.

Chaperonin facilitates protein folding by avoiding polypeptide collapse

This study shows that chaperonin-assisted folding starts from extended conformations and involves a tethered intermediate to prevent polypeptide collapse, differing from spontaneous folding.