Author

A. L. Nielsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

C. A. Olsen· 3 shared C. Moreno-Yruela· 2 shared J. E. Bolding· 2 shared M. Baek· 2 shared S. T. Jameson· 2 shared A. Lucidi· 1 shared A. S. Madsen· 1 shared D. Zhang· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

C. A. Olsen

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Author profile →

3 papers

Recent·Most cited

Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7

J. E. Bolding, A. L. Nielsen, I. Jensen, T. N. Hansen, L. A. Ryberg, S. T. Jameson, P. Harris, G. H. Peters, J. Denu, J. M. Rogers, C. A. Olsen

This study develops fluorogenic assays and cyclic peptide inhibitors to probe SIRT7 activity and selectivity, revealing its monomeric structure and substrate preferences.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Class I Histone Deacetylases (HDAC1-3) are Histone Lysine Delactylases

C. Moreno-Yruela, D. Zhang, W. Wei, M. Baek, J. Gao, A. L. Nielsen, J. E. Bolding, L. Yang, S. T. Jameson, J. Wong, C. A. Olsen, Y. Zhao

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

bioRxiv · Mar 24, 2021Biochemistry

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration

A. L. Nielsen, N. Rajabi, N. Kudo, K. L. Larsen, C. Moreno-Yruela, M. Baek, M. Fontenas, A. Lucidi, A. S. Madsen, M. Yoshida, C. A. Olsen

The paper develops potent, selective SIRT2 inhibitors with features suitable for cell culture and therapeutic development.

bioRxiv · Mar 20, 2020 · PreprintBiochemistry