Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells
M. Yao, A. S. Tijore, D. Cheng, J. V. Li, A. Hariharan, B. Martinac, G. Tran Van Nhieu, C. D. Cox, M. Sheetz
The paper shows Piezo1 binds to matrix adhesions in a force-dependent manner in normal cells, promoting adhesion maturation and calcium entry, but not in tumor cells.
bioRxiv · Mar 9, 2020Cell Biology