A. Hariharan

A latent cardiomyocyte regeneration potential in the human heart

This study shows that cardiomyocyte renewal is significantly reduced in end-stage heart failure but increases in patients with improved cardiac function from left ventricle support devices.

Heterogeneity of RNA editing in mesothelioma and how RNA editing enzyme ADAR2 affects mesothelioma cell growth, response to chemotherapy and tumor microenvironment

This study examines RNA editing heterogeneity in mesothelioma and shows ADAR2's role in cell growth, chemotherapy response, and tumor microenvironment regulation.

Ultrasound-mediated mechanical forces selectively kill tumor cells

This paper shows low-frequency ultrasound selectively kills tumor cells via a calpain-dependent mitochondrial pathway involving Piezo1 channels, with minimal damage to normal cells in animal models and patient-derived organoids.

Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells

The paper shows Piezo1 binds to matrix adhesions in a force-dependent manner in normal cells, promoting adhesion maturation and calcium entry, but not in tumor cells.

Both DNA binding domains of p53 are required for its ultra rapid recruitment to sites of UV damage

The paper shows p53 requires both DNA binding and C-terminal domains for ultra-rapid recruitment to UV damage sites, which is PARP-dependent and inhibited by cancer-associated mutations.

Mechanical Stretch Kills Transformed Cancer Cells

The paper shows that cyclic mechanical stretch induces apoptosis in transformed cancer cells but promotes growth in normal cells, with mechanoptosis driven by calcium influx and calpain activation.