Author

C. D. Cox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Bioengineering· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

B. Martinac· 5 shared D. Cheng· 2 shared g. Silvani· 2 shared J. V. Li· 2 shared L. A. Ju· 2 shared M. Yao· 2 shared V. Romanov· 2 shared A. Hariharan· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBioengineering

B. Martinac

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay

Y. Zhang, F. Jiang, Y. C. Zhao, Y. Wang, S. S. S. Aye, A.-N. Cho, G. Fang, C. D. Cox, H. Zreiqat, Z. F. Lu, H. Lu, L. A. Ju

This paper introduces a 3D spheroid-microvasculature-on-a-chip model to study tumor-endothelium mechanobiology interactions under controlled flow conditions.

bioRxiv · Nov 19, 2022Bioengineering

Membrane curvature governs the distribution of Piezo1 in live cells

S. Yang, X. Miao, S. Arnold, B. Li, A. T. Ly, H. Wang, M. Wang, X. Guo, M. M. Pathak, W. Zhao, C. D. Cox, Z. Shi

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

bioRxiv · Jun 22, 2022Biophysics

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

J. V. Li, C. A. Ng, D. Cheng, M. Yao, Y. Guo, Z.-Y. Yu, Y. Ramaswamy, L. A. Ju, P. W. Kuchel, M. P. Feneley, D. Fatkin, C. D. Cox

The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.

bioRxiv · Nov 30, 2020Biophysics

Biomechanical characterization of endothelial cells exposed to shear stress using acoustic force spectroscopy

g. Silvani, V. Romanov, C. D. Cox, B. Martinac

This study uses acoustic force spectroscopy to measure mechanical properties of endothelial cells under shear stress, showing force-dependent stiffness and contractile prestress changes.

bioRxiv · Sep 29, 2020Bioengineering

An acoustic platform for single-cell, high-throughput measurements of the viscoelastic properties of cells

V. Romanov, G. Silvani, H. Zhu, C. D. Cox, B. Martinac

This paper introduces an acoustic platform for high-throughput measurement of viscoelastic properties in adherent cells, showing temperature and pharmacological treatment effects on cell mechanics.

bioRxiv · Sep 7, 2020Bioengineering

Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells

M. Yao, A. S. Tijore, D. Cheng, J. V. Li, A. Hariharan, B. Martinac, G. Tran Van Nhieu, C. D. Cox, M. Sheetz

The paper shows Piezo1 binds to matrix adhesions in a force-dependent manner in normal cells, promoting adhesion maturation and calcium entry, but not in tumor cells.

bioRxiv · Mar 9, 2020Cell Biology

Membrane stiffness is a key determinant of E coli MscS channel mechanosensitivity

F. Xue, C. D. Cox, N. Bavi, P. R. Rohde, Y. Nakayama, B. Martinac

This study shows that membrane stiffness significantly affects the mechanosensitivity of E. coli MscS channels by altering tension response curves and reactivation behavior.

bioRxiv · Oct 4, 2019 · PreprintBiophysics

Disruption of membrane cholesterol organization impairs the concerted activity of PIEZO1 channel clusters

P. Ridone, E. Pandzic, M. Vassalli, C. D. Cox, A. Macmillan, P. A. Gottlieb, B. Martinac

This study shows that membrane cholesterol organization is critical for PIEZO1 channel cluster function, affecting their response to mechanical force and synchronization.

bioRxiv · Apr 11, 2019Biophysics