A. Sain

Olive phenolic compounds, potent tankyrase 1 inhibitor exhibit anti colon cancer effects by blocking Wnt/β-catenin pathway

This study identifies olive polyphenols as tankyrase 1 inhibitors that suppress the Wnt/β-catenin pathway, reducing colon cancer cell viability and target gene expression.

Apigenin exerts anti-cancer effects in colon cancer possibly by regulating Heat shock protein 90 alpha family class A member 1 (HSP90AA1)

This study identifies HSP90AA1 as a key target of apigenin in colon cancer, showing its anti-cancer effects through reduced HSP90AA1 expression and improved patient survival.

Chiral flows in the separating wall during cell division

The paper investigates chiral flows in the acto-myosin cortex during cell division in C. elegans embryos using PIV and hydrodynamic theory.

A specific mesh-like organization of human septin octameric complex drives membrane reshaping and curvature sensitivity

The paper investigates the organization and function of human septin octameric complexes at membranes, finding they form a mesh-like structure that drives membrane curvature sensitivity and reshaping.

Deformation of membrane vesicles due to chiral surface proteins

This study uses Monte-Carlo simulations to examine how chiral surface proteins influence the shape and orientation of deformable membrane vesicles.

Temperature-dependent Self assembly of biofilaments during red blood cell sickling

The paper studies the temperature-dependent lag time in hemoglobin fiber self-assembly using kinetic Monte-Carlo simulations, showing non-monotonic behavior with temperature changes.

Confined filaments in soft vesicles - case of sickle red blood cells

The paper studies shape deformations of red blood cells containing HbS fibers using elasticity and polymer models, finding that confinement leads to multipolar shapes and helical conformations.