Identification of unique and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
D. Akaberi, M. Pourghasemi Lati, J. Krambrich, J. Berger, G. Neilsen, E. Strandback, P. Turunen, J. Wannberg, H. Gullberg, M. Moche, P. K. Chinthakindi, T. Nyman, S. G. Sarafianos, A. Sandström, J. D. Järhult, , J. Lennerstrand
This paper identifies potent SARS-CoV-2 main protease inhibitors from a DNA-encoded chemical library using affinity-based selection, achieving an IC50 of 30 nM for compound SLL11.
bioRxiv · Mar 16, 2024Microbiology