S. G. Sarafianos

TSAR streamlines thermal shift assay analysis, identifying gallic acid and other metabolites that interact with HIV-1 capsid hexamers and may inhibit HIV-1 replication.

The paper tests nucleoside analogues for antiviral activity against orthopoxviruses, finding tenofovir and adefovir effective with low toxicity.

This study evaluates resistance to islatravir and tenofovir in HIV-1 strains with mutations K65R, M184V, and S68G/N, showing that their combination has a high genetic barrier to resistance.

This study identifies E166V as a key mutation conferring high nirmatrelvir resistance in SARS-CoV-2, with differential effects on Omicron and WA1 variants, and explores strategies to overcome resistance.

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

This paper develops SARS-CoV-2 replicon systems and cell lines for antiviral screening and mechanistic studies, enabling research at lower biosafety levels.

This study identifies HIV-1 capsid proteins as a nuclear import receptor that interacts with host nucleoporins and soluble factors to facilitate nuclear entry.

This study identifies mutations conferring resistance to EFdA in HIV-1, showing M184V as the primary determinant and A114S enhancing resistance.