Author

G. Neilsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

S. G. Sarafianos· 2 shared A. Emanuelli Castaner· 1 shared A. Lundkvist· 1 shared A. Sandström· 1 shared D. Akaberi· 1 shared E. Strandback· 1 shared H. Gullberg· 1 shared H. Zhang· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

S. G. Sarafianos

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Identification of unique and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

D. Akaberi, M. Pourghasemi Lati, J. Krambrich, J. Berger, G. Neilsen, E. Strandback, P. Turunen, J. Wannberg, H. Gullberg, M. Moche, P. K. Chinthakindi, T. Nyman, S. G. Sarafianos, A. Sandström, J. D. Järhult, , J. Lennerstrand

This paper identifies potent SARS-CoV-2 main protease inhibitors from a DNA-encoded chemical library using affinity-based selection, achieving an IC50 of 30 nM for compound SLL11.

bioRxiv · Mar 16, 2024Microbiology

Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies

S. Lan, G. Neilsen, R. L. Slack, W. A. Cantara, A. Emanuelli Castaner, Z. C. Lorson, N. D. Lulkin, H. Zhang, J. Lee, M. E. Cilento, P. R. Tedbury, S. G. Sarafianos

This study identifies E166V as a key mutation conferring high nirmatrelvir resistance in SARS-CoV-2, with differential effects on Omicron and WA1 variants, and explores strategies to overcome resistance.

bioRxiv · Dec 31, 2022 · PreprintMicrobiology