Author

A. Savino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

E. Monteleone· 2 shared L. Avalle· 2 shared P. Provero· 2 shared S. Di Carlo· 2 shared V. Poli· 2 shared A. Cattelan· 1 shared A. Griffa· 1 shared A. Viola· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

E. Monteleone

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Optimization of synthetic oscillatory biological networks through Reinforcement Learning

L. Giannantoni, A. Savino, S. Di Carlo

This study applies reinforcement learning to optimize synthetic biological networks by controlling Hopf bifurcations in ODE-based systems, showing its ability to identify bifurcation onset while facing challenges in persistent oscillations and computational speed.

bioRxiv · Nov 19, 2023Bioengineering

Neuronal Spike Shapes (NSS): A Straightforward Approach to Investigate Heterogeneity in Neuronal Excitability States.

L. Martini, G. Amprimo, S. Di Carlo, G. Olmo, C. Ferraris, A. Savino, R. Bardini

This paper introduces NSS, a method to analyze neuronal excitability states using AP waveforms, and validates it on murine cortical neurons, identifying voltage-gated K+ channels as markers of excitability states.

bioRxiv · Jun 28, 2023Bioengineering

RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity

R. Angioni, M. Bonfanti, N. Caporale, R. Sanchez-Rodriguez, F. Munari, A. Savino, D. Buratto, I. Pagani, N. Bertoldi, C. Zanon, P. Ferrari, E. Ricciardelli, C. Putaggio, S. Ghezzi, F. Elli, , G. Testa

The paper identifies RAGE as a novel receptor for SARS-CoV-2 that mediates monocyte infection and contributes to COVID-19 severity through single-cell analysis of immune responses.

bioRxiv · May 22, 2022Immunology

Network analysis allows to unravel breast cancer molecular features and to identify novel targets

A. Savino, L. Avalle, E. Monteleone, I. Miglio, A. Griffa, G. Accetta, P. Provero, V. Poli

This study uses network analysis on breast cancer gene expression data to identify molecular features and potential drug targets, particularly in basal-like breast cancer.

bioRxiv · Mar 6, 2019 · PreprintCancer Biology

SP1 and STAT3 functionally synergize to induce the RhoU small GTPase and a subclass of non-canonical WNT responsive genes correlating with poor prognosis in breast cancer.

E. Monteleone, V. Orecchia, P. Corrieri, D. Schiavone, L. Avalle, E. Moiso, A. Savino, I. Molineris, P. Provero, V. Poli

This study identifies SP1 and STAT3 cooperation in inducing RhoU and non-canonical WNT responsive genes linked to poor breast cancer prognosis.

bioRxiv · Aug 9, 2018Cancer Biology