Author

I. Pagani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 3 Assay:bulk RNA-seq· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Vicenzi· 6 shared S. Ghezzi· 4 shared A. Bisio· 2 shared E. A. Yates· 2 shared G. Poli· 2 shared M. A. Skidmore· 2 shared M. Clementi· 2 shared M. Guerrini· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersMicrobiology

E. Vicenzi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity

R. Angioni, M. Bonfanti, N. Caporale, R. Sanchez-Rodriguez, F. Munari, A. Savino, D. Buratto, I. Pagani, N. Bertoldi, C. Zanon, P. Ferrari, E. Ricciardelli, C. Putaggio, S. Ghezzi, F. Elli, , G. Testa

The paper identifies RAGE as a novel receptor for SARS-CoV-2 that mediates monocyte infection and contributes to COVID-19 severity through single-cell analysis of immune responses.

bioRxiv · May 22, 2022Immunology

Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding.

S. Bertini, A. Alekseeva, S. Elli, I. Pagani, S. Zanzoni, G. Eisele, R. Krishnan, K. P. Maag, C. Reiter, D. Lenhart, R. Gruber, E. A. Yates, E. Vicenzi, A. Naggi, A. Bisio, M. Guerrini

This study shows that pentosan polysulfate inhibits SARS-CoV-2 attachment and infection in vitro, with effectiveness comparable to heparin and better than low molecular weight heparin.

bioRxiv · Dec 19, 2021 · PreprintBiochemistry

Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells

I. Pagani, L. Ottoboni, P. Podini, S. Ghezzi, E. Brambilla, S. Bezukladova, D. Corti, M. E. Bianchi, M. R. Capobianchi, E. A. Yates, G. Martino, E. Vicenzi

bioRxiv · May 5, 2021 · PreprintMicrobiology

The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models

S. P. Davies, C. J. Mycroft-West, I. Pagani, H. J. Hill, Y.-H. Chen, R. T. Karlsson, I. Bagdonaite, S. E. Guimond, Z. Stamataki, M. A. Lima, J. E. Turnbull, Z. Yang, E. E. Vicenzi, M. A. Skidmore, F. Khanim, A. Richardson

This study shows fenofibrate and its metabolite fenofibric acid reduce SARS-CoV-2 infection in cell culture by up to 70% at clinically achievable concentrations.

bioRxiv · Jan 10, 2021Pharmacology & Toxicology

Rapid Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by Tungsten Trioxide-Based (WO3) Photocatalysis

S. Ghezzi, I. Pagani, G. Poli, S. Perboni, E. Vicenzi

This study demonstrates that a WO3 photocatalysis system inactivates SARS-CoV-2 by 100% within 30 minutes, despite only a 1.5 log10 reduction in viral RNA.

bioRxiv · Aug 1, 2020 · PreprintMicrobiology

Vinegar and Its Active Component Acetic Acid Inhibit SARS-CoV-2 Infection In Vitro and Ex Vivo

I. Pagani, S. Ghezzi, M. Clementi, G. Poli, M. Bussi, L. Pianta, M. Trimarchi, E. Vicenzi

This study shows vinegar and acetic acid inhibit SARS-CoV-2 infection in vitro and ex vivo, with enhanced effects at 45°C.

bioRxiv · Jul 8, 2020Microbiology

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.

C. Mycroft-West, D. Su, I. Pagani, T. Rudd, S. Elli, S. Guimond, G. Miller, M. Meneghetti, H. Nader, Y. Li, Q. Nunes, P. Procter, N. Mancini, M. Clementi, A. Bisio, , M. A. Skidmore

This study shows heparin inhibits SARS-CoV-2 invasion by binding to the Spike protein's RBD and inducing conformational changes, with structural features of heparin playing a key role.

bioRxiv · Apr 28, 2020Biochemistry