The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling
L. Sandner, M. Alteneder, R. Rica, B. Woller, E. Sala, T. Frey, A. Tosevska, C. Zhu, M. Madern, P. Hoffmann, A. Schebesta, I. Taniuchi, M. Bonelli, K. Schmetterer, M. Iannacone, , N. Boucheron
This study identifies Rin-like as a negative regulator of Tfh differentiation in mice and humans, showing its role in CD28 signaling and endocytosis.
bioRxiv · Jun 23, 2022Immunology