M. Iannacone

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness.

This study shows that inhibiting LSD1 enhances CD8+ T cell function in adoptive T cell therapy, leading to improved antitumor immunity and synergistic effects with anti-PDL1 therapy.

Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis

This paper identifies leptin receptor-expressing sympathetic perineurial cells that produce IL33, which prevents BAT inflammation and obesity by supporting thermogenesis and immune regulation.

A fluorescent reporter model for the visualization and characterization of TDC

This paper introduces a fluorescent reporter model to visualize and characterize TDC, showing their distinct gene signature and increased numbers during viral infection.

Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice

This study shows that nirmatrelvir treatment in SARS-CoV-2 infected mice reduces antibody and T cell responses, leading to weaker memory cell recruitment upon secondary challenge.

The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

This study identifies Rin-like as a negative regulator of Tfh differentiation in mice and humans, showing its role in CD28 signaling and endocytosis.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defineshyperactivated Tregs as a potential therapeutic target

This study identifies hyperactivated Tregs in iCCA as a therapeutic target through multimodal single-cell profiling of immune infiltrates.

Controlled administration of aerosolized SARS-CoV-2 to K18-hACE2 transgenic mice uncouples respiratory infection and anosmia from fatal neuroinvasion

This study develops an aerosolized SARS-CoV-2 infection model in K18-hACE2 mice that replicates respiratory symptoms without fatal neuroinvasion, offering a more accurate representation of human COVID-19 pathogenesis.

Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine

This study demonstrates that OMV-based SARS-CoV-2 vaccines induce neutralizing antibodies and protect mice from viral challenge.

Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration

This study investigates how intravenous ChAdOx1 nCov-19 vaccination leads to thrombocytopenia and immune responses against platelets, suggesting intramuscular injection as a safer alternative.

Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocyte accumulating hepatitis B surface antigen

CD8+ T cell priming in oral mucosa-draining lymph nodes supports systemic immunity

This study shows that CD8+ T cells are primed in mandibular lymph nodes after oral Listeria monocytogenes infection, contributing to systemic immunity.

Salivary gland macrophages assist tissue-resident CD8+ T cell immune surveillance

The paper uses imaging to show salivary gland TRM use unique motility and tissue macrophages assist in their surveillance.