Pharmacology & ToxicologybioRxivPreprint
Denaturation-sensitive BRET probes enable intracellular thermal shift measurements across diverse protein targets and biomolecular complexes
J. D. Vasta, A. Michaud, M. T. Beck…·Matthew B. Robers
This paper introduces BRETSA, a method for measuring thermal shifts in living cells, and demonstrates its application across 500+ proteins and biomolecular complexes.
DOI 10.64898/2026.11.10.765695