Author

M. T. Beck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

J. D. Vasta· 2 shared M. B. Robers· 2 shared A. Michaud· 1 shared B. F. Binkowski· 1 shared C. A. Zimprich· 1 shared C. R. Corona· 1 shared D. M. Peacock· 1 shared J. A. Walker· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

J. D. Vasta

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

X. Yang, J. L. Smith, M. T. Beck, J. M. Wilkinson, A. Michaud, J. D. Vasta, M. B. Robers, T. M. Willson

The paper develops a NanoBRET probe to measure PLK1 target engagement in live cells and evaluates its use with known PLK inhibitors.

bioRxiv · Feb 25, 2023 · PreprintCell Biology

KRAS is vulnerable to reversible switch-II pocket engagement in cells

J. D. Vasta, D. M. Peacock, Q. Zheng, J. A. Walker, Z. Zhang, C. A. Zimprich, M. R. Thomas, M. T. Beck, B. F. Binkowski, C. R. Corona, M. B. Robers, K. M. Shokat

The paper investigates the accessibility of the switch-II pocket in various KRAS mutants using NMR and a cellular engagement assay, showing it is accessible with non-covalent ligands regardless of GDP state.

Nature Chemical Biology · Mar 21, 2022Peer-reviewedCancer Biology