A. Shahar

Acetylation-dependent coupling between G6PD activity and apoptotic signaling

This study shows acetylation of G6PD regulates its activity and links to apoptotic signaling through structural and functional analyses.

Neutralization of the anthrax toxin by antibody-mediated stapling of its membrane penetrating loop

This study determines the cryo-EM structure of anthrax toxin's protective antigen complexed with an antibody, revealing how the antibody neutralizes the toxin by preventing pore formation.

The metal binding site composition of the cation diffusion facilitator protein MamM cytoplasmic domain impacts its metal responsivity

This study investigates how mutations in the metal binding sites of the MamM CTD affect its conformation and metal binding properties using X-ray crystallography and Trp-fluorescence spectrometry.

The inter-dimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase

This study shows that the inter-dimeric interface of U. urealiticum MAT regulates catalytic activity and structural stability through conformational changes induced by product binding.

Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine

This study genetically encodes acetyl-lysine into STAT3 to investigate its effects on structure and DNA binding, revealing that acetylation does not directly alter these properties but may require additional factors for transcriptional regulation.