Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing Mcl-1-addicted cancer cells
F. Sneyers, M. Kerkhofs, K. Welkenhuyzen, F. Speelman-Rooms, A. Shemy, A. R. Voet, G. Eelen, M. Dewerchin, S. Tait, B. Ghesquiere, M. D. Bootman, G. Bultynck
This paper shows that BAPTAi inhibits PFKFB3, reducing mTORC1-driven Mcl-1 translation and killing Mcl-1-dependent cancer cells, independent of Ca2+ signaling.
bioRxiv · Oct 31, 2022 · PreprintCell Biology