A. Sotiropoulos

Transient hypoxia followed by progressive reoxygenation is required for efficient skeletal muscle repair through Rev-ERBalpha modulation

This study shows that transient hypoxia followed by reoxygenation is essential for skeletal muscle repair, mediated by Rev-ERBalpha regulation of myogenesis.

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth

This study shows RhoA in myofibers promotes hypertrophy by regulating satellite cell fusion through ECM remodeling and macrophage recruitment without affecting protein synthesis.

Single-nucleus RNA-seq and FISH reveal coordinated transcriptional activity in mammalian myofibers

The paper uses snRNA-seq and FISH to show that myonuclei within mammalian myofibers are coordinately expressed, primarily expressing one Myh isoform and showing synchronization early in development.

The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network

This study shows SMYD3 promotes myogenesis by activating the myogenin regulatory network through transcriptomic analysis in murine myoblasts.

The nature and intensity of mechanical stimulation drive different dynamics of MRTF-A nuclear redistribution after actin remodeling in myoblasts

This study investigates how different mechanical stimuli affect MRTF-A nuclear redistribution in myoblasts, showing varied dynamics linked to actin polymerization and depolymerization.