Author

J. Dilworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Ecology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

C. Drury· 3 shared K. Nakka· 3 shared A. Sorisky· 2 shared C. Caruso· 2 shared J. McDonald· 2 shared K. Dauner· 2 shared N. Verma· 2 shared X. Zha· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersEcology

C. Drury

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

SMCHD1 activates the expression of genes required for the expansion of human myoblasts

M. M.-K. Wong, E. Gardner, L. A. Megeney, C. P. Emerson, D. P. Gabellini, J. Dilworth

This study shows SMCHD1 activates cell cycle genes in human myoblasts, promoting proliferation independently of DUX4, and identifies LAP2 as a key target gene.

bioRxiv · Feb 4, 2024Cell Biology

Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3

Z. Saiioum, K. Dauner, Y.-f. Li, N. Verma, V. Almendro-Vedia, D. VALDIVIESO GONZALEZ, D. J. Zhang, K. Nakka, J. McDonald, A. Sorisky, B.-L. Song, I. Lopez Montero, J. Luo, J. Dilworth, X. Zha

This study shows statins reduce macrophage cholesterol, upregulate JMJD3, and shift macrophage activation toward anti-inflammatory responses in both M1 and M2 states.

bioRxiv · Jan 9, 2023Biochemistry

Fine-scale variability in coral bleaching and mortality during a marine heatwave

S. Yadav, T. Roach, M. J. McWilliam, C. Caruso, M. Rocha de Souza, C. Foley, C. Allen, J. Dilworth, J. Huckeba, E. P. Santoro, R. Wold, J. Simpson, S. Miller, J. R. Hancock, C. Drury, J. S. Madin

This study tracks coral bleaching and mortality during a marine heatwave, finding that spatial and taxonomic differences in bleaching are driven by environmental factors, habitat complexity, and species composition.

bioRxiv · Nov 1, 2022Ecology

Reducing Cholesterol in Resting Macrophage Activates NF-kB through Mitochondria, Resulting in Epigenomic Reprogramming to Dampen Inflammation in Activated Macrophages

X. Zha, Z. Salloum, K. Dauner, K. Nakka, N. Verma, H. Bandukwala, A. Sorisky, J. Dilworth, D. V. Gonzalez, V. A. Vedia, I. Lopez-Montero, J. McDonald, C. D. Corley

bioRxiv · Feb 10, 2022 · PreprintCell Biology

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

M. Dos Santos, S. Backer, F. Aurade, M. Wong, M. Wurmser, R. Pierre, F. Langa, M. Do Cruzeiro, A. Schmitt, J.-P. Concordet, A. Sotiropoulos, J. Dilworth, D. Noordermeer, F. Relaix, I. Sakakibara, P. Maire

bioRxiv · Apr 17, 2021Cell Biology

Host genotype and stable differences in algal symbiont communities explain patterns of thermal stress response of Montipora capitata following thermal pre-exposure and across multiple bleaching events

J. Dilworth, C. Caruso, V. A. Kahkejian, A. C. Baker, C. Drury

This study shows that thermal stress response in corals depends on host genotype, temperature regime, and stable symbiont community differences, with no protective effect from pre-treatment.

bioRxiv · Jul 24, 2020Ecology

Metabolomic signatures of coral bleaching history

T. N. F. Roach, J. Dilworth, C. Martin H., A. D. Jones, R. A. Quinn, C. Drury

This study identifies metabolomic signatures linked to coral bleaching history, showing that prior bleaching affects both coral and algal biochemistry and influences thermal stress responses.

bioRxiv · May 10, 2020Ecology

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

Q. Wu, D. Heidenreich, S. Zhou, S. Ackloo, G. Deblois, S. Duan, K. Nakka, J. Dilworth, M. Lupien, P. E. Brennan, C. H. Arrowsmith, S. Mueller, O. Fedorov, P. Filippakopoulos, S. Knapp

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.

bioRxiv · Aug 14, 2018Cell Biology