Single-cell characterization of subsolid and solid lesions in the lung adenocarcinoma spectrum
J. Yanagawa, L. M. Tran, E. Fung, W. D. Wallace, A. E. Prosper, G. A. Fishbein, C. Shea, R. Hong, B. Liu, R. Salehi-Rad, J. Z. Deng, A. Gower, J. D. Campbell, S. A. Mazzilli, J. Beane, , S. M. Dubinett
The paper uses single-cell RNA sequencing to compare immune and non-immune cell features in subsolid, solid, and non-involved lung tissues, finding reduced cytolytic activity and increased regulatory T cells in subsolid lesions.
bioRxiv · Dec 25, 2020 · PreprintCancer Biology