J. D. Campbell

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

Protection of Hamsters Challenged with SARS-CoV-2 Variants of Concern by Two Doses of MVC-COV1901 Vaccine Followed by a Single Dose of Beta Variant Version of MVC-COV1901

This study evaluates the efficacy of a vaccine regimen using wildtype and Beta variant S-2P in hamsters against SARS-CoV-2 Delta and VoCs, showing improved neutralization and protection with a mixed-dose schedule.

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

Functional and structural modifications of influenza antibodies during pregnancy

This study examines how influenza antibodies change structurally and functionally during pregnancy, showing reduced inflammation and increased antibody retention.

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

This study shows that CpG-adjuvanted S-2P vaccine protected hamsters from SARS-CoV-2 infection by inducing high neutralizing antibodies and reducing viral load.

Single-cell characterization of subsolid and solid lesions in the lung adenocarcinoma spectrum

The paper uses single-cell RNA sequencing to compare immune and non-immune cell features in subsolid, solid, and non-involved lung tissues, finding reduced cytolytic activity and increased regulatory T cells in subsolid lesions.

Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

This paper develops a subunit vaccine against COVID-19 using CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen and shows it induces high neutralizing antibody titers and Th1 response in mice.

Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19

The paper isolates and rapidly expands SARS-CoV-2-specific CD4+ and CD8+ T cells from convalescent donors under GMP standards, maintaining a central memory phenotype for therapeutic use in COVID-19.

Whole genome doubling confers unique genetic vulnerabilities on tumor cells

The paper identifies genetic vulnerabilities in WGD+ tumor cells and shows that KIF18A is specifically required for their viability.

Molecular Subtyping reveals Immune Alterations associated with Progression of Bronchial Premalignant Lesions

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.

Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays

The paper develops a method to identify new cancer genes by integrating protein network analysis with in vivo tumorigenesis assays, finding 62 new candidates and validating two in patient data.