S. M. Dubinett

Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma

This study shows glucose deprivation in lung adenocarcinoma causes de-differentiation and an aggressive phenotype through epigenetic changes and HIF1 activation.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

Image quantification technique reveals novel lung cancer cytoskeletal phenotype with partial EMT signature

The paper identifies an intermediate EMT state with a specific cytoskeletal signature using image quantification tools and tracks EMT progression and drug responses.

Single-cell characterization of subsolid and solid lesions in the lung adenocarcinoma spectrum

The paper uses single-cell RNA sequencing to compare immune and non-immune cell features in subsolid, solid, and non-involved lung tissues, finding reduced cytolytic activity and increased regulatory T cells in subsolid lesions.

Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden

This paper develops novel Kras-mutant murine NSCLC models with increased TMB and co-occurring mutations, showing enhanced anti-PD-1 efficacy but immunosuppressed TMEs in some models.

Molecular Subtyping reveals Immune Alterations associated with Progression of Bronchial Premalignant Lesions

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.