Author

H. Kadara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:cell-cell communication· 3 Assay:scRNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

I. I. Wistuba· 3 shared J. V. Heymach· 3 shared A. E. Spira· 2 shared A. Sinjab· 2 shared B. Sepesi· 2 shared C. Behrens· 2 shared C. S. Stevenson· 2 shared D. L. Gibbons· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

I. I. Wistuba

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6 papers

Recent·Most cited

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

G. Han, A. Sinjab, Z. Rahal, A. M. Lynch, W. Treekitkarnmongkol, Y. Liu, A. G. Serrano, J. Feng, K. Liang, K. Khan, W. Lu, S. Hernandez, Y. Liu, X. Cao, E. Dai, , H. Kadara

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

bioRxiv · May 13, 2022Cancer Biology

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

C. Bartolacci, C. Andreani, G. Dias do Vale, S. Berto, M. Melegari, A. C. Crouch, D. L. Baluya, G. Kemble, K. Hodges, J. Starrett, K. Politi, S. L. Starnes, D. Lorenzini, M. G. Raso, L. Solis Soto, , P. P. Scaglioni

This study identifies FASN as a therapeutic target in KRAS-mutant lung cancer by showing its role in lipid metabolism and ferroptosis induction.

bioRxiv · Mar 18, 2021Cancer Biology

Single-cell characterization of subsolid and solid lesions in the lung adenocarcinoma spectrum

J. Yanagawa, L. M. Tran, E. Fung, W. D. Wallace, A. E. Prosper, G. A. Fishbein, C. Shea, R. Hong, B. Liu, R. Salehi-Rad, J. Z. Deng, A. Gower, J. D. Campbell, S. A. Mazzilli, J. Beane, , S. M. Dubinett

The paper uses single-cell RNA sequencing to compare immune and non-immune cell features in subsolid, solid, and non-involved lung tissues, finding reduced cytolytic activity and increased regulatory T cells in subsolid lesions.

bioRxiv · Dec 25, 2020 · PreprintCancer Biology

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

A. Sinjab, G. Han, W. Treekitkarnmongkol, K. Kobayashi, P. Brennan, M. Dang, D. Hao, R. Wang, E. Dai, H. Dejima, J. Zhang, E. Bogatenkova, B. Sanchez-Espiridion, K. Chang, D. R. Little, , H. Kadara

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

C. A. Stewart, C. M. Gay, K. Ramkumar, K. R. Cargill, R. J. Cardnell, M. B. Nilsson, S. Heeke, E. M. Park, S. T. Kundu, L. Diao, Q. Wang, L. Shen, Y. Xi, B. Zhang, C. M. Della Corte, , L. A. Byers

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

bioRxiv · May 28, 2020 · PreprintCancer Biology

Specific Inhibition of GSK-3β by Tideglusib: Potential Therapeutic Target for Neuroblastoma Cancer Stem Cells

H. F. Bahmad, R. M. Chalhoub, H. Harati, J. Bou-Gharios, F. Ballout, A. Monzer, H. Msheik, S. Assi, T. Araji, M. K. Elajami, P. Ghanem, F. Chamaa, H. Kadara, T. Abou-Antoun, G. Daoud, , W. Abou-Kheir

This study evaluates Tideglusib's effectiveness in inhibiting neuroblastoma cell proliferation, viability, migration, and CSC self-renewal both in vitro and in vivo.

bioRxiv · Feb 18, 2020 · PreprintCancer Biology