PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors.
M. A. Roelli, D. Ruffieux-Daidie, A. Stooss, O. ElMokh, W. A. Phillips, M. S. Dettmer, R.-P. Charles
This study shows that PIK3CAH1047R mutations cause resistance to BRAFV600E inhibitors in thyroid tumors by paradoxically activating the ERK pathway.
bioRxiv · Jul 18, 2017Cancer Biology