W. A. Phillips

Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy

This study shows targeting a STING agonist to perivascular macrophages in ADT-treated prostate tumors delays castration resistance prostate cancer onset.

Caspase-2 protects against ferroptotic cell death

This study shows caspase-2 protects mutant-p53 cancer cells from ferroptotic death by non-proteolytically interacting with proteins to limit GPX4 degradation.

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response than TP53 mutation status

This study identifies SLC7A11 expression as a better predictor of response to APR-246 than TP53 mutation status using cell line data and functional validation.

Bayesian modelling of BAC firing as a mechanism for apical amplification in neocortical pyramidal neurons

The paper presents a Bayesian model of BAC firing in pyramidal neurons to show how apical inputs can amplify basal responses without corrupting the signal, suggesting a new framework for understanding cortical function.

Serum glycoprotein biomarker validation for esophageal adenocarcinoma and application to Barrett’s surveillance

The paper validates serum glycoprotein biomarkers for esophageal adenocarcinoma and develops a panel for Barrett’s surveillance.

PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors.

This study shows that PIK3CAH1047R mutations cause resistance to BRAFV600E inhibitors in thyroid tumors by paradoxically activating the ERK pathway.