Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy
S. Nishio, C. Emori, B. Wiseman, D. Fahrenkamp, E. Dioguardi, S. Zamora-Caballero, M. Bokhove, L. Han, A. Stsiapanava, Y. Lu, M. Kodani, R. E. Bainbridge, K. M. Komondor, A. E. Carlson, M. Landreh, , L. Jovine
This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.
bioRxiv · Jun 21, 2023Biophysics