Author

L. Jovine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:protein structure prediction· 3 Approach:deep learning· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2

Frequent Co-Authors

L. Han· 4 shared S. Nishio· 3 shared A. Elofsson· 2 shared A. Stsiapanava· 2 shared D. de Sanctis· 2 shared E. Dioguardi· 2 shared M. Landreh· 2 shared S. Yasumasu· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiophysics

L. Han

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Author profile →

6 papers

Recent·Most cited

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

A. Elofsson, L. Han, E. Bianchi, G. J. Wright, L. Jovine

The paper uses AlphaFold-Multimer to predict a pentameric complex involved in mammalian egg-sperm fusion, including TMEM81, a previously uncharacterized sperm protein.

bioRxiv · Jul 27, 2023Biophysics

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

S. Nishio, C. Emori, B. Wiseman, D. Fahrenkamp, E. Dioguardi, S. Zamora-Caballero, M. Bokhove, L. Han, A. Stsiapanava, Y. Lu, M. Kodani, R. E. Bainbridge, K. M. Komondor, A. E. Carlson, M. Landreh, , L. Jovine

This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.

bioRxiv · Jun 21, 2023Biophysics

Complementing machine learning-based structure predictions with native mass spectrometry

T. M. Allison, M. T. Degiacomi, E. G. Marklund, L. Jovine, A. Elofsson, J. L. Benesch, M. Landreh

This study shows that native mass spectrometry can reveal structural features not detectable by AlphaFold2, improving the accuracy of protein structure models.

bioRxiv · Mar 17, 2022Biophysics

Discovery of archaeal Fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

D. Moi, S. Nishio, X. Li, C. Valansi, M. Langleib, N. G. Brukman, K. Flyak, C. Dessimoz, D. de Sanctis, K. Tunyasuvunakool, J. Jumper, M. Grana, H. Romero, P. S. Aguilar, L. Jovine, B. Podbilewicz

The paper identifies archaeal proteins homologous to eukaryotic gamete fusion proteins and shows they can mediate cell fusion.

bioRxiv · Oct 13, 2021Evolutionary Biology

Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

A. Stsiapanava, C. Xu, M. Brunati, S. Zamora-Caballero, C. Schaeffer, L. Han, M. Carroni, S. Yasumasu, L. Rampoldi, B. Wu, L. Jovine

The paper reports the cryo-EM structure of native human uromodulin, revealing its filamentous conformation and mechanism of bacterial binding.

bioRxiv · May 28, 2020Biophysics

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

K. Nishimura, E. Dioguardi, S. Nishio, A. Villa, L. Han, T. Matsuda, L. Jovine

The paper identifies ZP1 cross-linking as crucial for human ZP assembly and explores its modulation by fucosylation and zinc sparks, suggesting it as a target for non-hormonal contraception.

bioRxiv · Mar 28, 2019Biophysics