Author

M. Landreh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:protein structure· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Sahin· 4 shared A. Rising· 3 shared D. Lama· 3 shared A. Elofsson· 2 shared A. Leppert· 2 shared D. P. Lane· 2 shared E. G. Marklund· 2 shared G. Chen· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersBiochemistry

C. Sahin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A suicidal and extensively disordered luciferase with a bright luminescence

F. M. Dijkema, M. I. Escarpizo-Lorenzana, M. K. Nordentoft, H. C. Rabe, C. Sahin, M. Landreh, R. M. Branca, E. S. Sorensen, B. S. Christensen, A. Prestel, K. Teilum, J. R. Winther

This paper investigates the structure and mechanism of Gaussia luciferase, revealing its disordered structure and identifying key residues for light production and inactivation.

Protein Science · Jul 18, 2024Peer-reviewedBiochemistry

Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions.

A. Leppert, F. Jianhui, V. Railaite, T. Bohn Pessatti, C. Morman, H. Osterholz, F. R. N. C. Maia, M. B. Linder, A. Rising, M. Landreh

This paper demonstrates laser-induced control of sol-gel transitions in protein condensates to enable drug loading.

bioRxiv · Mar 12, 2024 · PreprintBiophysics

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

S. Nishio, C. Emori, B. Wiseman, D. Fahrenkamp, E. Dioguardi, S. Zamora-Caballero, M. Bokhove, L. Han, A. Stsiapanava, Y. Lu, M. Kodani, R. E. Bainbridge, K. M. Komondor, A. E. Carlson, M. Landreh, , L. Jovine

This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.

bioRxiv · Jun 21, 2023Biophysics

Dual stop codon suppression in mammalian cells with genomically integrated genetic code expansion machinery

B. Meineke, J. Heimgärtner, R. Caridha, M. Block, K. J. Kimler, M. F. Pires, M. Landreh, S. J. Elsässer

This paper demonstrates genomic integration of stop codon suppression systems in mammalian cells to enable homogeneous incorporation of noncanonical amino acids for dual fluorophore labeling.

bioRxiv · Mar 26, 2023Cell Biology

A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1

M. Saluri, A. Leppert, G. V. Gese, C. Sahin, D. Lama, M. Kaldmae, G. Chen, A. Elofsson, T. M. Allison, M. Arsenian-Henriksson, D. P. Lane, J. Johansson, B. M. Hallberg, M. Landreh

The paper investigates how NPM1 self-assembly and chaperone activity interact, finding that oligomerization modulates its ability to prevent amyloid formation.

bioRxiv · Sep 29, 2022 · PreprintBiophysics

Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures

C. Sahin, A. Motso, X. Gu, H. Feyrer, D. Lama, T. Arndt, A. Rising, G. V. Gese, B. M. Hällberg, E. G. Marklund, N. P. Schafer, K. Petzold, K. Teilum, P. G. Wolynes, M. Landreh

The paper uses mass spectrometry and simulations to study phase separation of RNA-binding proteins, revealing distinct assembly mechanisms and droplet structures.

bioRxiv · Sep 28, 2022Biophysics

Complementing machine learning-based structure predictions with native mass spectrometry

T. M. Allison, M. T. Degiacomi, E. G. Marklund, L. Jovine, A. Elofsson, J. L. Benesch, M. Landreh

This study shows that native mass spectrometry can reveal structural features not detectable by AlphaFold2, improving the accuracy of protein structure models.

bioRxiv · Mar 17, 2022Biophysics

A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

M. Kaldmae, T. Vosselman, X. Zhong, D. Lama, G. Chen, M. Saluri, N. Kronqvist, J. W. Siau, A. S. Ng, F. J. Ghadessy, P. Sabatier, B. Vojtesek, M. Sarr, C. Sahin, N. Osterlund, , M. Landreh

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

bioRxiv · Feb 22, 2021 · PreprintBiochemistry