Leptin promotes expression of EMT-related transcription factors and invasion in a Src and FAK-dependent pathway in MCF10A mammary epithelial cells
M. Olea-Flores, M. Zuniga-Eulogio, A. Tacuba-Saavedra, M. Bueno-Salgado, A. Sanchez-Carvajal, Y. Vargas-Santiago, M. A. Mendoza-Catalan, E. Perez Salazar, A. Garcia-Hernandez, T. Padilla-Benavides, N. Navarro-Tito
This study shows leptin induces EMT and invasion in MCF10A cells via Src and FAK activation, increasing Twist and β-catenin expression and MMP secretion.
bioRxiv · Aug 18, 2019Cell Biology