Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma
M. A. Vittoria, N. M. Kingston, E. Xia, R. Hong, L. Huang, S. McDonald, A. Tilston-Lunel, R. Darp, J. Campbell, D. Lang, X. Xu, C. J. Ceol, X. Varelas, N. J. Ganem
This study shows that the Hippo tumor suppressor pathway is activated in growth-arrested melanocytes, preventing melanoma development, and its inactivation allows BRAF-driven melanoma formation.
bioRxiv · May 4, 2021Cancer Biology